• John R Tuttle, Scott A Ritterman, Dale B Cassidy, Walter A Anazonwu, John A Froehlich, and Lee E Rubin.
• Department of Orthopaedics, Brown University Alpert School of Medicine, Providence, Rhode Island.
• J Arthroplasty. 2014 Aug 1;29(8):1512-5.

AbstractThe purpose of this study was to provide a cost-benefit analysis of topical tranexamic acid (TXA) in primary total hip and knee arthroplasty patients. A retrospective cohort of 591 consecutive patients, 311 experimental and 280 control, revealed a transfusion rate reduction from 17.5% to 5.5%, increased postoperative hemoglobin, and decreased delta hemoglobin without an increase in adverse events (all P < 0.001). This led to saving $83.73 per patient based on transfusion costs alone after accounting for the cost of TXA. Hospital disposition to home compared to subacute nursing facility was also significantly increased by 9.3% (P < 0.02). We conclude that topical TXA reduces transfusion rate, increases home disposition, and reduces cost in primary hip and knee arthroplasty.Copyright © 2014 Elsevier Inc. All rights reserved.

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