• Neuroscience letters · Aug 1994

    omega-Conotoxin GVIA binds to and blocks rat neuromuscular junction.

    • G Rossoni, F Berti, L La Maestra, and F Clementi.
    • Department of Pharmacology, University of Milan, Italy.
    • Neurosci. Lett. 1994 Aug 1;176(2):185-8.

    AbstractThe effect of omega-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that 125I-omega-conotoxin binds to rat tibialis muscle end-plate; that omega-conotoxin blocks the neuromuscular transmission both in vivo, in the sciatic nerve-tibialis anterior muscle, and in vitro in the isolated phrenic nerve-diaphragm preparation; and does not affect muscle nicotinic receptors. We conclude that in rat neuromuscular junctions N-type calcium channels are important for neurotransmitter secretion.

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