• Chung-Tat Lun, Veronica L Chan, Wah-Shing Leung, Alice P S Cheung, Suet-Lai Cheng, Miranda S N Tsui, and Chung-Ming Chu.
• Division of Respiratory Medicine, Department of Medicine, United Christian Hospital, Hong Kong SAR, China.
• Respirology. 2013 Jul 1;18(5):814-9.

Background And ObjectivePatients with chronic obstructive pulmonary disease (COPD) presenting with acute hypercapnic respiratory failure (AHcRF) benefit from non-invasive ventilation (NIV). The best way to withdraw NIV is not known, and we conducted a pilot study comparing stepwise versus immediate withdrawal of NIV in these patients.MethodsThis was a prospective, single-centre, open-labelled randomized study comparing stepwise versus immediate withdrawal of NIV in patients with COPD exacerbation recovering from AHcRF. The primary end-point was the success rate of NIV withdrawal, defined as no restarting of NIV from randomization to 48 h after complete withdrawal of NIV.ResultsSixty patients were randomized, 35 patients to stepwise withdrawal and 25 patients to immediate withdrawal. The two study arms were clinically comparable. There was no statistically significant difference in the success rate, with NIV successfully stopped in 74.3% and 56% in the stepwise and immediate withdrawal groups, respectively (P = 0.139).ConclusionsWe could not show any benefits for either strategy to withdraw NIV. The study may have been underpowered to detect differences, and larger prospective studies are required.© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

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