• Neural Regen Res · Aug 2013

    Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment.

    • Liping Chen, Zhigao Sun, Fawei Wang, Chengyong Xu, Miao Geng, Hongyan Chen, and Dongmei Duan.
    • Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
    • Neural Regen Res. 2013 Aug 5;8(22):2060-8.

    AbstractThe Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.

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