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- Gerald M Aronoff, Michael J Brennan, Douglas D Pritchard, and Brian Ginsberg.
- Carolina Pain Associates, Presbyterian Orthopedic Hospital, Charlotte, NC 28207, USA. geraldaronoffmd@msn.com
- Pain Med. 2005 Jul 1;6(4):305-14.
ObjectiveTo review the evidence for dosing and efficacy of oral transmucosal fentanyl citrate in the management of pain and produce dosing guidelines.DesignThe scientific literature pertaining to oral transmucosal fentanyl citrate was reviewed, focusing upon its pharmacology and clinical experience with use in cancer and noncancer pain. Emphasis was upon published, peer-reviewed English language articles.ResultsInformation was crucially examined and synthesized into guidelines for use and dosing of oral transmucosal fentanyl citrate in cancer and noncancer pain.ConclusionsOral transmucosal fentanyl citrate is a potent opioid delivery system, which, when used appropriately, is an effective treatment option for pain. Adherence to guidelines should promote its safe and efficacious use in a variety of clinical pain management settings.
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