• Neurology · Jun 1994

    Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

    • W D Parker, N J Mahr, C M Filley, J K Parks, D Hughes, D A Young, and C M Cullum.
    • Department of Neurology, University of Colorado School of Medicine, Denver.
    • Neurology. 1994 Jun 1;44(6):1086-90.

    AbstractWe evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec-1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec-1/mg, p = 0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.

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