• Hong-min Zhang, Da-wei Liu, Xiao-ting Wang, Xi Rui, Hao Wang, Huai-wu He, Ye Liu, and Xiu-kai Chen.
• Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
• Zhonghua Nei Ke Za Zhi. 2010 Jul 1;49(7):610-3.

ObjectiveTo evaluate fluid responsiveness by stroke volume variation(SVV) in mechanically ventilated patients with refractory septic shock.MethodsForty-two refractory septic shock patients were enrolled in the study. According to the responsiveness of fluid loading, the patients were divided into responsive group and non-responsive group. The SVV values of two groups were retrospectively analyzed. The receiver operating characteristic curve was drafted to determine the cut-off value of SVV for predicting fluid responsiveness.ResultsAmong the 42 refractory septic shock patients, 24 were found responsive to fluid loading, 18 were not; before the fluid loading, central venous pressure, heart rate, mean arterial pressure and global end-diastolic volume index in the both groups showed no significant differences whereas the SVV in the responsive group was much higher than that in the nonresponsive group (P=0.006). Using SVV≥12% as the threshold to predict fluid responsiveness, the sensitivity was 77%, specificity was 85%.ConclusionSVV can accurately predict fluid responsiveness in refractory septic shock patients.

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