• Jean S Kutner, Marlaine C Smith, Lisa Corbin, Linnea Hemphill, Kathryn Benton, B Karen Mellis, Brenda Beaty, Sue Felton, Traci E Yamashita, Lucinda L Bryant, and Diane L Fairclough.
• School of Medicine, College of Nursing, University of Colorado Denver, Denver and Aurora, Colorado, USA. jean.kutner@ucdenver.edu
• Ann. Intern. Med. 2008 Sep 16;149(6):369-79.

BackgroundSmall studies of variable quality suggest that massage therapy may relieve pain and other symptoms.ObjectiveTo evaluate the efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer.DesignMultisite, randomized clinical trial.SettingPopulation-based Palliative Care Research Network.Patients380 adults with advanced cancer who were experiencing moderate-to-severe pain; 90% were enrolled in hospice.InterventionSix 30-minute massage or simple-touch sessions over 2 weeks.MeasurementsPrimary outcomes were immediate (Memorial Pain Assessment Card, 0- to 10-point scale) and sustained (Brief Pain Inventory [BPI], 0- to 10-point scale) change in pain. Secondary outcomes were immediate change in mood (Memorial Pain Assessment Card) and 60-second heart and respiratory rates and sustained change in quality of life (McGill Quality of Life Questionnaire, 0- to 10-point scale), symptom distress (Memorial Symptom Assessment Scale, 0- to 4-point scale), and analgesic medication use (parenteral morphine equivalents [mg/d]). Immediate outcomes were obtained just before and after each treatment session. Sustained outcomes were obtained at baseline and weekly for 3 weeks.Results298 persons were included in the immediate outcome analysis and 348 in the sustained outcome analysis. A total of 82 persons did not receive any allocated study treatments (37 massage patients, 45 control participants). Both groups demonstrated immediate improvement in pain (massage, -1.87 points [95% CI, -2.07 to -1.67 points]; control, -0.97 point [CI, -1.18 to -0.76 points]) and mood (massage, 1.58 points [CI, 1.40 to 1.76 points]; control, 0.97 point [CI, 0.78 to 1.16 points]). Massage was superior for both immediate pain and mood (mean difference, 0.90 and 0.61 points, respectively; P < 0.001). No between-group mean differences occurred over time in sustained pain (BPI mean pain, 0.07 point [CI, -0.23 to 0.37 points]; BPI worst pain, -0.14 point [CI, -0.59 to 0.31 points]), quality of life (McGill Quality of Life Questionnaire overall, 0.08 point [CI, -0.37 to 0.53 points]), symptom distress (Memorial Symptom Assessment Scale global distress index, -0.002 point [CI, -0.12 to 0.12 points]), or analgesic medication use (parenteral morphine equivalents, -0.10 mg/d [CI, -0.25 to 0.05 mg/d]).LimitationsThe immediate outcome measures were obtained by unblinded study therapists, possibly leading to reporting bias and the overestimation of a beneficial effect. The generalizability to all patients with advanced cancer is uncertain. The differential beneficial effect of massage therapy over simple touch is not conclusive without a usual care control group.ConclusionMassage may have immediately beneficial effects on pain and mood among patients with advanced cancer. Given the lack of sustained effects and the observed improvements in both study groups, the potential benefits of attention and simple touch should also be considered in this patient population.

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