• Eduardo Rodriguez-Noriega, Esteban Gonzalez-Diaz, Rayo Morfin-Otero, Gerardo F Gomez-Abundis, Jaime Briseño-Ramirez, Hector Raul Perez-Gomez, Hugo Lopez-Gatell, Celia M Alpuche-Aranda, Ernesto Ramírez, Irma López, Miguel Iguala, Ietza Bojórquez Chapela, Ethel Palacios Zavala, Mauricio Hernández, Tammy L Stuart, Margarita Elsa Villarino, Marc-Alain Widdowson, Steve Waterman, Timothy Uyeki, Eduardo Azziz-Baumgartner, and Hospital Civil de Guadalajara, Fray Antonio Alcalde Emerging Respiratory Infections Response Team.
• Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco, México.
• Plos One. 2010 Jan 1;5(5):e10658.

BackgroundPandemic influenza A (H1N1) virus emerged during 2009. To help clinicians triage adults with acute respiratory illness, a scoring system for influenza-like illness (ILI) was implemented at Hospital Civil de Guadalajara, Mexico.MethodsA medical history, laboratory and radiology results were collected on emergency room (ER) patients with acute respiratory illness to calculate an ILI-score. Patients were evaluated for admission by their ILI-score and clinicians' assessment of risk for developing complications. Nasal and throat swabs were collected from intermediate and high-risk patients for influenza testing by RT-PCR. The disposition and ILI-score of those oseltamivir-treated versus untreated, clinical characteristics of 2009 pandemic influenza A (H1N1) patients versus test-negative patients were compared by Pearson's Chi(2), Fisher's Exact, and Wilcoxon rank-sum tests.ResultsOf 1840 ER patients, 230 were initially hospitalized (mean ILI-score = 15), and the rest were discharged, including 286 ambulatory patients given oseltamivir (median ILI-score = 11), and 1324 untreated (median ILI-score = 5). Fourteen (1%) untreated patients returned, and 3 were hospitalized on oseltamivir (median ILI-score = 19). Of 371 patients tested by RT-PCR, 104 (28%) had pandemic influenza and 42 (11%) had seasonal influenza A detected. Twenty (91%) of 22 imaged hospitalized pandemic influenza patients had bilateral infiltrates compared to 23 (38%) of 61 imaged hospital test-negative patients (p<0.001). One patient with confirmed pandemic influenza presented 6 days after symptom onset, required mechanical ventilation, and died.ConclusionsThe triaging system that used an ILI-score complimented clinicians' judgment of who needed oseltamivir and inpatient care and helped hospital staff manage a surge in demand for services.

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