• I A TenVaarwerk, G A Jessurun, M J DeJongste, C Andersen, C Mannheimer, T Eliasson, W Tadema, and M J Staal.
• Department of Cardiology, Thoraxcenter, University Hospital of Groningen, PO Box 30,001, 9700 RB Groningen, The Netherlands.
• Heart. 1999 Jul 1;82(1):82-8.

ObjectiveTo determine morbidity and mortality characteristics in patients treated with electrical neuromodulation for refractory angina pectoris.DesignA retrospective multicentre study of patients treated with spinal cord stimulation between 1987 and 1997; 21 centres were contacted and 14 responded.SettingSpecialist centres worldwide.PatientsQuestionnaires were returned on 517 patients, of whom 71% were male. One was lost to follow up. Mean (SD) age was 63.9 (10.1) years. Duration of angina pectoris was 8.1 (6.3) years.ResultsBefore spinal cord stimulation, 66% of the patients had experienced myocardial infarction, 68% had three vessel disease, and in 24% the left ventricular ejection fraction (LVEF) was /= 71 years were independent predictors of mortality. During spinal cord stimulation, New York Heart Association functional class improved from 3.5 to 2.1 (p < 0.01); 25 of the deceased patients (24%) and 32 survivors (8%) experienced myocardial infarction; hospital admissions were significantly (p < 0.001) more common in the deceased group (66% v 37%).ConclusionsThe clinical outcome of patients with intractable angina is not adversely affected by the chronic use of neurostimulation.

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