• Y Fujii, H Tanaka, and T Kawasaki.
• Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan. yfujii@igaku.md.tsukuba.ac.jp
• Eur J Surg. 2001 Mar 1;167(3):184-7.

ObjectiveTo evaluate the efficacy and safety of oral granisetron for the prevention of postoperative nausea and vomiting after breast surgery.DesignProspective, randomised, double-blind, placebo-controlled study.SettingUniversity affiliated hospital, Japan.Subjects100 women listed for partial or modified radical mastectomy with or without axillary dissection.InterventionsPatients were given either placebo or granisetron in three different doses (1 mg, 2 mg, 4 mg) orally 1 hour preoperatively (n = 25 in each group). A standard general anaesthetic technique and postoperative analgesia were used.Main Outcome MeasuresAll episodes of nausea and vomiting during the first 24 hours after anaesthesia.ResultsComplete response, defined as no nausea and vomiting and no need for a "rescue" antiemetic, during the first 24 hours after anaesthesia was recorded in 13 (52%) with placebo, 14 (56%) with granisetron 1 mg, 22 (88%) with 2 mg, and 22 (88%) with 4 mg, respectively (p = 0.006, Fisher's exact test). No clinically serious adverse events were seen in any of the groups.ConclusionPreoperative oral granisetron, in doses of more than 2 mg, is effective for the prevention of postoperative nausea and vomiting in women undergoing general anaesthesia for breast surgery.

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