-
- P Krieger, J Tegnér, A el Manira, and S Grillner.
- Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
- Neuroreport. 1994 Sep 8;5(14):1760-2.
AbstractThe effects of the metabotropic glutamate receptor (mGluR) agonist ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) on single neurones and on the network underlying locomotion in the lamprey have been analysed. ACPD induces a depolarization in lamprey spinal cord neurones, which is insensitive to tetrodotoxin (TTX) and ionotropic glutamate receptor antagonists, but is reversibly blocked by the mGluR antagonist MCPG ((+)-alpha-methyl-4-carboxyphenylglycine). The ACPD-induced depolarization persists in a calcium-free solution or when the calcium channel blocker cadmium is added to the solution. At the network level ACPD causes an increased burst frequency during fictive locomotion by increasing the excitability level of network neurones.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..