• Journal of neurotrauma · Jun 2010

    Acute gonadotroph and somatotroph hormonal suppression after traumatic brain injury.

    • Justin Wagner, Joshua R Dusick, David L McArthur, Pejman Cohan, Christina Wang, Ronald Swerdloff, W John Boscardin, and Daniel F Kelly.
    • University of Southern California Keck School of Medicine, Los Angeles, California, USA.
    • J. Neurotrauma. 2010 Jun 1;27(6):1007-19.

    AbstractHormonal dysfunction is a known consequence of moderate and severe traumatic brain injury (TBI). In this study we determined the incidence, time course, and clinical correlates of acute post-TBI gonadotroph and somatotroph dysfunction. Patients had daily measurement of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, estradiol, growth hormone, and insulin-like growth factor-1 (IGF-1) for up to 10 days post-injury. Values below the fifth percentile of a healthy cohort were considered abnormal, as were non-measurable growth hormone (GH) values. Outcome measures were frequency and time course of hormonal suppression, injury characteristics, and Glasgow Outcome Scale (GOS) score. The cohort consisted of 101 patients (82% males; mean age 35 years; Glasgow Coma Scale [GCS] score

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