• Hand clinics · Feb 2016

    Review

    New Concepts in Complex Regional Pain Syndrome.

    • Maral Tajerian and John David Clark.
    • Anesthesia Service, Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA; Department of Anesthesiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
    • Hand Clin. 2016 Feb 1; 32 (1): 41-9.

    AbstractDespite the severe pain and disability associated with complex regional pain syndrome (CRPS), the lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating to both the physician and the patient. The review highlights some of the mechanisms thought to be involved in the pathophysiology of CRPS in preclinical models and CRPS patients, with the ultimate goal that understanding these mechanisms will lead to the design of efficacious, mechanism-based treatments available to the clinic. Published by Elsevier Inc.

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