• Control Clin Trials · Jun 1981

    Introduction to sample size determination and power analysis for clinical trials.

    • J M Lachin.
    • Control Clin Trials. 1981 Jun 1;2(2):93-113.

    AbstractThe importance of sample size evaluation in clinical trials is reviewed and a general method is presented from which specific equations are derived for sample size determination or the analysis of power for a wide variety os statistical procedures. The method is discussed and illustrated in relation to the t test, tests for proportions, tests of survival time, and tests for correlations as they commonly occur in clinical trials. Most of the specific equations reduce to a simple general form for which tables are presented.

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