• Sachie Ogawa, Hiroaki Seino, Hiroshi Ito, Shinya Yamazaki, Steven Ganzberg, and Hiroyoshi Kawaai.
• Department of Dental Anesthesiology, Ohu University School of Dentistry, Fukushima, Japan. maromaro@ce.mbn.or.jp
• Anesth Prog. 2008 Jan 1;55(3):82-8.

AbstractThis study investigated the physiologic and sedative parameters associated with a low-dose infusion of dexmedetomidine (Dex). Thirteen healthy volunteers were sedated with Dex at a loading dose of 6 mcg/kg/h for 5 minutes and a continuous infusion dose of 0.2 mcg/kg/h for 25 minutes. The recovery process was observed for 60 minutes post infusion. The tidal volume decreased significantly despite nonsignificant changes in respiratory rate, minute ventilation, oxygen saturation, and end-tidal carbon dioxide. The mean arterial pressure and heart rate also decreased significantly but within clinically acceptable levels. Amnesia to pin prick was present in 69% of subjects. A Trieger dot test plot error ratio did not show a significant change at 30 minutes post infusion despite a continued significant decrease in bispectral index. We conclude that sedation with a low dose of Dex appears to be safe and potentially efficacious for young healthy patients undergoing dental procedures.

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