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Clinical pediatrics · Dec 2012
Comparative StudySerial procalcitonin levels to detect bacteremia in febrile neutropenia.
- Aaron J Reitman, Rhonda M Pisk, John V Gates, and J Daniel Ozeran.
- University of California, San Francisco-Fresno, Fresno, CA 90027, USA. Aaron@DrReitman.com
- Clin Pediatr (Phila). 2012 Dec 1;51(12):1175-83.
BackgroundOur objective was to evaluate serial procalcitonin (PCT) levels compared with an initial PCT level at admission in predicting bacteremia in pediatric febrile neutropenic oncology patients.ProcedureSerum PCT levels were measured at admission (t0) and within 24 hours of admission (t1) in pediatric oncology patients presenting with fever and neutropenia. A blood culture was collected at t0 and monitored for 5 days for bacterial growth. PCT value of 0.5 ng/mL at either t0 or t1 was considered predictive for bacteremia.ResultsPCT levels were significantly higher in children with positive blood cultures than with negative blood cultures. Serial PCT values mirrored t1 values. Serial PCT showed 76% specificity and negative predictive value of 93% in ruling out bacteremia.ConclusionElevated PCT levels are predictive of bacteremia. Using serial PCT levels within 24 hours allowed a better prediction of bacteremia than the PCT level at t0.
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