• Vet Hum Toxicol · Feb 2002

    A lipid emulsion reduces mortality from clomipramine overdose in rats.

    • Goor Yoav, Goor Odelia, Cabilil Shaltiel, Yoav Goor, Odelia Goor, and Shaltiel Cabili.
    • Department of Internal Medicine 6, Tel Aviv Sourasky Medical Centre, Israel.
    • Vet Hum Toxicol. 2002 Feb 1;44(1):30.

    AbstractTricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.

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