• Marika Fallenius, Rahul Raj, Matti Reinikainen, Stepani Bendel, and Markus B Skrifvars.
• 1Division of Intensive Care, Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.2Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.3Department of Anesthesiology and Intensive Care, North Karelia Central Hospital, Joensuu, Finland.4Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.
• Crit. Care Med. 2016 Jan 1;44(1):180-7.

ObjectiveTo determine the relation between high arterial oxygen tension levels (PaO2) and long-term mortality in patients with spontaneous intracerebral hemorrhage treated in the ICU.DesignNational observational multicenter cohort study.SettingTwenty-one ICUs in Finland.PatientsA total of 3,033 adult patients.InterventionsNone.Measurements And Main ResultsPatients were divided into high (> 150 mm Hg), intermediate (97.5-150 mm Hg), and low (< 97.5 mm Hg) PaO2 groups based on the lowest measured PaO2/FIO2 ratio during the first 24 hours after ICU admission: 63% (n = 1,923) were in the low group, 29% (n = 892) were in the intermediate group, and 7% (n = 218) were in the high group; 80% were mechanically ventilated. The primary outcome was 6-month mortality, which occurred in 49% of patients and was significantly more frequent in the high PaO2 group than in the intermediate and low PaO2 groups (61% vs 52% and 46%, respectively, p < 0.001). In univariate analysis, patients in the high PaO2 group had a significantly increased risk of 6-month mortality compared with the low PaO2 group (odds ratio, 1.82; 95% CIs, 1.36-2.42; p < 0.001), but this statistically significant relation was lost after adjusting for markers of severity of illness in a logistic mixed-effects regression model (odds ratio, 1.10; 95% CI, 0.76-1.60; p = 0.598).ConclusionsNo significant relation between PaO2 levels and long-term mortality was found. The clinical role of hyperoxemia in patients with intracerebral hemorrhage treated in the ICU remains controversial and warrants further studies.

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