• Molecular immunology · Oct 2013

    Letter

    A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients.

    • A L Wadley, P R Kamerman, C S N Chew, Z Lombard, C L Cherry, and P Price.
    • Mol. Immunol. 2013 Oct 1;55(3-4):197-9.

    IntroductionAnimal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort.Method342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy.ResultsIL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association.DiscussionWe identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.Copyright © 2013 Elsevier Ltd. All rights reserved.

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