• Cheng-Che Shen, Albert C Yang, Benjamin Ing-Tiau Kuo, and Shih-Jen Tsai.
• From the Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital; Department of Information Management, National Chung-Cheng University, Chiayi; Department of Psychiatry, and Department of Research and Medication, Taipei Veterans General Hospital; School of Medicine, National Yang-Ming University, Taipei, Taiwan.C.C. Shen, MD, Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital; A.C. Yang, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University; B.I. Kuo, MD, PhD, Department of Research and Medication, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University; S.J. Tsai, MD, Department of Psychiatry, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University.
• J Rheumatol. 2015 Jul 1; 42 (7): 1203-8.

ObjectivePrimary Sjögren syndrome (pSS) is a chronic autoimmune disease. A clear temporal causal relationship between pSS and psychiatric disorders has not been well established. We used a nationwide population-based retrospective cohort study to explore the relationship between pSS and the subsequent development of psychiatric disorders.MethodsWe identified subjects who were newly diagnosed with pSS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database. A comparison cohort was constructed for patients without pSS. There were 2686 patients with pSS and 10,744 matched controls observed until diagnosed with psychiatric disorders or until death, withdrawal from the NHI system, or December 31, 2009. The Institutional Review Board of Taipei Veterans General Hospital approved this study (2012-12-013BC).ResultsThe adjusted HR of depressive disorder, anxiety disorder, and sleep disorder in subjects with pSS were significantly higher at 1.829, 1.856, and 1.967 than those of the controls during the followup. We found that pSS might increase the risk of subsequent newly diagnosed depressive disorder, anxiety disorder, and sleep disorder that may impair life quality.ConclusionOur findings highlight the need for psychiatric evaluation and intervention for patients with pSS.

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