• Br J Clin Pract · Sep 1996

    Review

    Advances in the treatment of schizophrenia.

    • G R Kuperberg and R Murray.
    • Maudsley Hospital, London.
    • Br J Clin Pract. 1996 Sep 1;50(6):315-23.

    AbstractWe review advances in the treatment of schizophrenia. We begin with an overview of antipsychotic drug development, focusing on the in vitro and in vivo binding profiles of clozapine and a new generation of D2:5HT antagonists. We then consider the main barriers to effective treatment: non-compliance (and side-effects) of medication, recurrent relapse, 'treatment resistance', negative symptoms and neurocognitive deficits. Within this framework, we review the mechanisms of action and clinical uses of the 'atypical' antipsychotic drugs. We also show how a variety of psychosocial interventions, particularly those that incorporate cognitive techniques, can be used in combination with pharmacotherapy to overcome the same clinical hurdles.

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