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Am J Hosp Palliat Care · May 2014
Clinical TrialUse of methylphenidate for the management of fatigue in Chinese patients with cancer.
- Steven W K Siu, Martin Law, Rico K Y Liu, K H Wong, Inda S Soong, Annie O L Kwok, K H Ng, P T Lam, and T W Leung.
- 1Department of Clinical Oncology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
- Am J Hosp Palliat Care. 2014 May 1;31(3):281-6.
UnlabelledREASON FOR THE STUDY: Studies on methylphenidate for cancer-related fatigue showed conflicting results. This prospective study aims to determine whether methylphenidate is useful for relieving fatigue in Chinese patients with cancer. Chinese Version of Brief Fatigue Inventory (BFI-C) was administered on days 1, 8, and 29. Methylphenidate dose on day 1 was 5 mg daily then adjusted after day 8 according to response and side effects tolerance.Main FindingsOnly 48% of the 25 recruited patients were on methylphenidate by day 29. Overall, no significant improvement in fatigue level was observed after methylphenidate, though benefits were shown in subgroups with age ≤ 65 and higher baseline BFI-C values.Principal ConclusionsMethylphenidate may be useful for management of cancer-related fatigue in selected Chinese patients.
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