• Jia-shu Zhang, Xiao-lei Chen, Fang-ye Li, Jin-jiang Li, Gang Zheng, Ting Zhang, Shen Hu, and Bai-nan Xu.
• Department of Neurosurgery, PLA General Hospital, Beijing 100853, China.
• Zhonghua Yi Xue Za Zhi. 2012 Jun 5;92(21):1468-71.

ObjectiveTo evaluate the clinical value of VarioGuide in stereotactic brain biopsy.MethodsFifteen patients with brain lesions underwent frameless stereotactic brain biopsy guided by VarioGuide and multimodal neuronavigation. Intraoperative magnetic resonance imaging (iMRI) was used to confirm the accuracy of biopsy. And the VarioGuide-related adverse events, operative duration, surgical outcomes and postoperative complications were recorded respectively.ResultsIn all patients, VarioGuide and multimodal neuronavigation were successfully integrated into the biopsy procedure. No VarioGuide-related adverse events were reported. The mean operative duration was (65 ± 8) min. The biopsy accuracy was confirmed by iMRI in all cases. And the postoperative histological diagnostic rate was 100%. No mortality and morbidity occurred postoperatively.ConclusionThe combined approach of VarioGuide and multimodal neuronavigation is accurate, safe and efficient. It may improve the histological diagnostic rate without postoperative neurological deficits in stereotactic brain biopsy.

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