• J. Cell. Biochem. · Aug 2015

    Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin.

    • Shaofeng Yan, Xiao Han, Hao Xue, Ping Zhang, Xing Guo, Tong Li, Xiaofan Guo, Guang Yuan, Lin Deng, and Gang Li.
    • Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong Province, P.R., China.
    • J. Cell. Biochem. 2015 Aug 1; 116 (8): 1680-92.

    AbstractGlioma is one of the most aggressive and malignant tumor types. Despite advances in surgery, imaging, chemotherapy, and radiation, glioma patient prognosis remains poor. Glioma pathogenesis is an urgent problem that must be solved. MicroRNAs (miRNAs) are endogenous small non-coding RNAs that are key post-transcriptional regulators of gene expression. miRNA deregulation commonly occurs in human tumorigenesis. In the present study, the expression levels of Let-7f were down-regulated in both glioma tissues and glioma cells. The enhanced expression of Let-7f suppressed glioma cells proliferation, migration, and invasion via direct targeting perisotin oncogenic activity. Experiments with periostin siRNA or over-expression further suggest that Let-7f may serve as tumor suppressors through perisotin signal. These findings provide insights regarding the role and mechanism of Let-7f in regulating biological behavior of glioma cells via the Let-7f/periostin axis, and Let-7f may serve as a potential therapeutic target in glioma.© 2015 Wiley Periodicals, Inc.

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