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Case Reports
Renal thrombotic microangiopathy caused by interferon beta-1a treatment for multiple sclerosis.
- Julien Mahe, Aurélie Meurette, Anne Moreau, Caroline Vercel, and Pascale Jolliet.
- Clinical Pharmacology Department, Institute of Biology, University Hospital, Nantes, France. julien.mahe@chu-nantes.fr
- Drug Des Dev Ther. 2013 Jan 1;7:723-8.
AbstractInterferon beta-1a is available as an immunomodulating agent for relapsing forms of multiple sclerosis. Common side effects include flu-like symptoms, asthenia, anorexia, and administration site reaction. Kidney disorders are rarely reported. In this study we describe the case of a woman who has been undergoing treatment with interferon beta-1a for multiple sclerosis for 5 years. She developed a hemolytic-uremic syndrome with intravascular hemolysis in a context of severe hypertension. A kidney biopsy showed a thrombotic microangiopathy. This observation highlights an uncommon side effect of long-term interferon beta-1a therapy. Pathophysiological mechanisms leading to this complication might be explained by the antiangiogenic activity of interferon.
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