• Ned Tijdschr Geneeskd · Jan 2013

    Case Reports

    [Vismodegib in metastasized basal cell carcinoma].

    • M G H C Marieke Reinders, Luc Dirix, Klara Mosterd, and Remco van Doorn.
    • MUMC, afd. Dermatologie, Maastricht, the Netherlands. marieke.reinders@mumc.nl
    • Ned Tijdschr Geneeskd. 2013 Jan 1;157(12):A6011.

    BackgroundGenerally basal cell carcinoma can be simply and curatively treated. However, large and long-standing tumours can be locally very destructive and in rare cases even metastasize. Hedgehog pathway inhibitors such as vismodegib constitute a new and promising therapy for metastatic or locally advanced basal cell carcinoma.Case DescriptionWe describe a patient with metastasized basal cell carcinoma and basal cell nevus syndrome who, in the context of a study, was successfully treated with vismodegib. The main undesirable effects in our patient were muscle cramps, loss of taste, nausea and hair loss.ConclusionBasal cell carcinoma is potentially a locally destructive skin tumour that only very rarely metastasizes. Hedgehog pathway inhibitors such as vismodegib can be administered in a selected group of patients with basal cell carcinoma.

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