• Bing Dai, Jian Kang, Zan-feng Wang, De-lei Kong, Wei Tan, and Hong-wen Zhao.
• Department of Respiratory Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
• Zhonghua Yi Xue Za Zhi. 2010 Sep 14;90(34):2392-5.

ObjectiveTo analyze the risk factors of novel severe influenza A (H1N1) with concurrent adult respiratory distress syndrome (ARDS).MethodsA multivariable Logistic regression analysis was conducted for ARDS risk factors in controlled clinical trials for comparing the clinical features between the ARDS and non-ARDS groups and comparing ARDS patients' lymphocyte counts and T lymphocyte subsets between the smoking and non-smoking groups through a retrospective analysis of 92 novel influenza A (H1N1) patients who admitted to our hospital from October 2009 to January 2010.ResultsThrough a single factor analysis between ARDS and non-ARDS groups, the comparisons in the factors including smoking (17 cases vs 11 cases), T lymphocyte subsets, lactate dehydrogenase (LDH), initial treatment point of oseltamivir and initial oxygen flow greater than 2 L/min (28 cases vs 18 cases) had statistically significant differences (all P<0.05). The comparison in T lymphocyte subsets had statistically significant difference between the smoking and non-smoking groups in ARDS patients (all P<0.05). The multivariable Logistic regression analysis showed that smoking (P=0.027, OR=8.05, 95%CI: 1.28-50.80) and initial oxygen flow greater than 2 L/min (P=0.010, OR=16.70, 95%CI: 3.29-84.84) were relevant to the incidence of ARDS in novel influenza A (H1N1) patients.ConclusionSmoking and initial oxygen flow greater than 2 L/min were the risk factors of novel severe influenza A (H1N1) with concurrent ARDS.

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