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- Mauro Gallitelli and Michele Alzetta.
- Department of Emergency Medicine, "Santi Giovanni e Paolo" Hospital, Venice, Italy. Electronic address: mauro.gallitelli@libero.it.
- Am J Emerg Med. 2012 Oct 1;30(8):1664.e1-2.
AbstractAngioedema related to the use of angiotensin-converting enzyme inhibitors (AE-ACEi) has, so far, been treated with antiallergic drugs with questionable results. Because angioedema in this setting is likely related to increased levels of bradikinin, we decided to use icatibant, a bradikinin receptor antagonist licensed for use in hereditary angioedema, in a patient with AE-ACEi. In the same patient, the time to resolution of the angioedema during previous attacks was about 2 days when classic antiallergic drug regimens were used; when icatibant was used, this time shortened to 10 hours. Icatibant is a promising drug in the treatment of AE-ACEi.Copyright © 2012 Elsevier Inc. All rights reserved.
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