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- Matthieu Legrand, Joaquim Mateo, Alice Aribaud, Sixtine Ginisty, Pirayeh Eftekhari, Patrice Tran Ba Huy, Ludovic Drouet, and Didier Payen.
- Department of Anesthesiology and Critical Care, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris 7 Denis Diderot, 2 rue Ambroise-Paré, 75475 Paris CEDEX 10, France. matthieu.m.legrand@gmail.com
- Arch. Intern. Med. 2011 Jul 25;171(14):1285-6.
AbstractRecent approval by the US Food and Drug Administration (FDA) of dabigatran etexilate, an oral direct thrombin inhibitor, for the prevention of stroke in patients with atrial fibrillation will likely extend its administration in elderly patients. The risk of major overdosage of dabigatran etexilate in this population is, however, much increased owing to frequent renal function impairment, low body weight, drug interactions that cannot be detected with a routine coagulation test, and no antagonist available. We report herein 2 clinical cases, including 1 fatal case, illustrating our concern regarding the risk of bleeding events in elderly patients.
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