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- G A Arndt, W G Reiss, K A Bathke, S R Springman, and G Kenny.
- Department of Anesthesiology, University of Wisconsin Medical School, Madison, USA.
- Pharmacotherapy. 1995 Jul 1;15(4):512-6.
AbstractPropofol was administered intravenously using a first-order, three-compartment, computer-controlled infusion pump (CCIP) based on the Ohmeda 9000 syringe pump. The CCIP system produced a target-controlled infusion (TCI) based on the estimated blood concentration (EBC). Twenty-five patients undergoing ambulatory surgery completed the study. The induction EBC was 4.72 +/- 0.28 micrograms/ml, and was achieved rapidly with minimal hemodynamic changes. The emergence EBC was 1.55 +/- 0.21 micrograms/ml, and the discharge EBC was 1.06 +/- 0.22 micrograms/ml. The EBC, together with clinical signs, allowed for predictable inductance and emergence from anesthesia using propofol.
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