• Nozomu Sakai, Callisia N Clarke, Rebecca Schuster, John Blanchard, Amit D Tevar, Michael J Edwards, and Alex B Lentsch.
• Department of Surgery, University of Cincinnati, Cincinnati, OH 45267-0558, United States.
• World J. Gastroenterol. 2010 Aug 14;16(30):3816-26.

AimTo investigate the mechanisms of liver growth and atrophy after portal vein ligation (PVL) and its effects on tumor growth.MethodsMice were subjected to PVL, partial hepatectomy, or sham surgery. The morphological alterations, activation of transcription factors, and expression of cytokines and growth factors involved in liver regeneration were evaluated. In a separate set of experiments, murine colorectal carcinoma cells were injected via the portal vein and the effect of each operation on liver tumor growth was studied.ResultsLiver regeneration after PVL and partial hepatectomy were very similar. In ligated lobes, various cytokines, transcription factors and regulatory factors were significantly upregulated compared to non-ligated lobes after PVL. Atrophy in ligated lobes was a result of early necrosis followed by later apoptosis. Tumor growth was significantly accelerated in ligated compared to non-ligated lobes.ConclusionTumor growth was accelerated in ligated liver lobes and appeared to be a result of increased growth factor expression.

32 keywords...

hide…