• Yunus Tanglay, Raphael Twerenbold, Gino Lee, Max Wagener, Ursina Honegger, Christian Puelacher, Tobias Reichlin, Seoung Mann, Seoung Man Sou, Sophie Druey, Thomas Hochgruber, Stephan Zürcher, Milos Radosavac, Philipp Kreutzinger, Gilles Pretre, Fabio Stallone, Petra Hillinger, Cedric Jaeger, Maria Rubini Gimenez, Michael Freese, Damian Wild, Katharina Rentsch, Stefan Osswald, Michael J Zellweger, and Christian Mueller.
• Department of Cardiology, University Hospital Basel, Switzerland; Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland.
• Am. J. Med. 2015 Jun 1;128(6):638-46.

BackgroundThe aim of this study was to investigate the value of a novel high-sensitivity cardiac troponin I measurement to rule out exercise-induced myocardial ischemia in patients without known coronary artery disease.MethodsWe included 714 patients without previously known coronary artery disease who were referred for rest/stress myocardial perfusion single photon emission tomography. All clinical information available to the treating cardiologist was used to quantify the clinical judgment regarding the presence of exercise-induced myocardial ischemia using a visual analogue scale twice: once before and once after bicycle exercise stress testing. High-sensitivity cardiac troponin I measurements were obtained before stress testing in a blinded manner. The presence of exercise-induced myocardial ischemia was adjudicated on the basis of myocardial perfusion single photon emission tomography combined with coronary angiography findings.ResultsExercise-induced myocardial ischemia was detected in 167 participants (23.4%). High-sensitivity cardiac troponin I levels were significantly higher in patients with exercise-induced myocardial ischemia (4.0 ng/L [95% confidence interval, 2.8-8.6] vs 2.6 ng/L [95% confidence interval, 1.8-4.1], P < .001) and remained an independent predictor of ischemia in multivariable analysis (P < .001). Combining clinical judgment before exercise testing with high-sensitivity cardiac troponin I levels increased diagnostic accuracy as quantified by the area under the receiver operating curve from 0.64 to 0.73 (P < .001), which also tended to be superior to clinical judgment after exercise testing (0.69, P = .056). A single resting high-sensitivity cardiac troponin I measurement provided similar diagnostic accuracy as integrated clinical judgment after exercise testing including work load, as well as symptoms and electrocardiogram changes (0.70 vs 0.69, P = not significant).ConclusionsHigh-sensitivity cardiac troponin I measurements seem to complement noninvasive clinical assessment in patients with suspected coronary artery disease.Copyright © 2015 Elsevier Inc. All rights reserved.

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