• J. Neurol. Sci. · Sep 2007

    Randomized Controlled Trial

    Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.

    • Wilhelm J Schulte-Mattler, Oliver Opatz, Wendelin Blersch, Arne May, Hans Bigalke, and Kai Wohlfahrt.
    • Department of Neurology, University of Regensburg, Universitätsstr. 84, 93053 Regensburg, Germany. wilhelm.schulte-mattler@klinik.uni-regensburg.de
    • J. Neurol. Sci. 2007 Sep 15;260(1-2):38-42.

    AbstractA genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans.

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