• Yann-Fen C Chao, Yin-Yin Chen, Kai-Wei Katherine Wang, Ru-Pin Lee, and Hweifar Tsai.
• College of Nursing, Taipei Medical University, Taipei, Taiwan. yfchao@tmu.edu.tw
• J Clin Nurs. 2009 Jan 1;18(1):22-8.

AimThe purpose of this study was to explore the effect of oral secretion on aspiration and reducing ventilator-associated pneumonia.BackgroundVentilator-associated pneumonia is a serious hospital-acquired infection with reported incidence rate of 12.2% and mortality rate of 29.3%. Oral secretion is purported as a media which brings the oropharyngeal pathogens down to the respiratory track.MethodsTwo-group comparison study design was adopted. Subjects were recruited from an adult general intensive care unit of a medical centre in Taipei city. Patients in the study group received suction of oral secretion before each positional care, in contrast with patients in the control group who received routine care.ResultsVentilator-associated pneumonia was found in 24 of 159 (15.1%) patients in the control group and in five of 102 (4.9%) patients in the study group with a reduction of risk ratio of 0.32 (95% CI 0.11-0.92). Eight of the 24 ventilator-associated pneumonia patients died in the control group; however, none of those ventilator-associated pneumonia patients died in the study group. The increased chance of survival was 1.50 (95% CI 1.13-1.99). The length of stay in ICU and duration of mechanical ventilation were reduced in the study group. In consideration of cost, the cost of tubes used to remove oral secretion is much less than the one used to do continuous subglottal suction.ConclusionRemoval of oral secretion is effective in reducing the incidence of ventilator-associated pneumonia with minimum cost intervention.Relevance To Clinical PracticeThis study provides evidence that removal of oral secretion prior to position change is cost effective to reduce the incidence of ventilator-associated pneumonia. As such intervention is an easy task, routine removal of oral secretion is recommended as the standard of daily nursing care of patients on ventilator.

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