• Br J Anaesth · Feb 1999

    Randomized Controlled Trial Comparative Study Clinical Trial

    I.v. diclofenac and ketorolac for pain after thoracoscopic surgery.

    • K Perttunen, E Nilsson, and E Kalso.
    • Department of Anaesthesia, Helsinki University Central Hospital, Finland.
    • Br J Anaesth. 1999 Feb 1;82(2):221-7.

    AbstractWe studied intensity of pain, cumulative morphine consumption, ventilatory and renal function, and haemostasis in patients undergoing video-assisted thoracoscopic surgery and receiving a 2-day i.v. infusion of diclofenac, ketorolac or saline. Plasma concentrations of the two NSAID were also measured. The study was randomized, double-blind and placebo-controlled, with 10 patients in each group. Patients experienced mainly moderate pain. Mean consumption of i.v. morphine during the first day after operation was 57 (SEM 11) mg in the placebo group. Diclofenac and ketorolac were equally effective in reducing total morphine consumption (61% and 52%, respectively). Adverse events were similar and minor. Greater variability in plasma concentrations of ketorolac were detected compared with diclofenac.

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