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Rev Bras Anestesiol · Sep 2008
ReviewThe role of peripheral opiate antagonists in pain medicine and perioperative care.
- Pedro Paulo Tanaka and Jonathan Moss.
- CET/SBA do Hospital de Clinicas da Universidade Federal do Parana (UFPR), Curitiba, PR.
- Rev Bras Anestesiol. 2008 Sep 1;58(5):540-7, 533-9.
Background And ObjectivesPre-clinical and clinical trials of peripheral opiate antagonists have shed new light on the effects of exogenous and endogenous opioids.ContentsThis article review preclinical studies and clinical opioid bowel disfunction trials.ConclusionsIf approved these drugs may offer potential solutions to important clinical problems in pain management.
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