• Acta Psychiatr Scand · Feb 1998

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Double-blind study of the efficacy and safety of milnacipran and imipramine in elderly patients with major depressive episode.

    • J Tignol, J Pujol-Domenech, J P Chartres, J M Léger, Y Plétan, I Tonelli, A Tournoux, and N Pezous.
    • Department of Psychiatry, Hôpital Charles Perrens, Bordeaux, France.
    • Acta Psychiatr Scand. 1998 Feb 1;97(2):157-65.

    AbstractThe novel antidepressant agent milnacipran is a dual and equipotent serotonin and noradrenaline reuptake inhibitor. The aim of this double-blind study was to compare the efficacy and safety of milnacipran (50 mg twice daily) with that of imipramine (50 mg twice daily) in elderly patients with major depressive episode. A total of 219 patients were randomly assigned to 8 weeks of double-blind treatment with either milnacipran or imipramine; 72 patients withdrew from the study. At the end of treatment no significant differences were found between milnacipran and imipramine in antidepressant efficacy. A significantly greater number of side-effects, particularly anticholinergic effects, was observed in the imipramine group. Milnacipran may be preferable to imipramine in elderly depressed patients, as it provides the same antidepressant activity as imipramine with a lower incidence of side-effects, and does not impair cognitive ability.

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