• Fuqiang Gao, Wei Sun, Wanshou Guo, Zirong Li, Weiguo Wang, and Liming Cheng.
• Osteonecrosis and Joint-Preserving and Reconstruction Center, Beijing, China; Department of Orthopedic Surgery, Beijing, China; Beijing Key Laboratory of Arthritic and Rheumatic Diseases, Beijing, China; China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing, China.
• J Arthroplasty. 2015 Aug 1; 30 (8): 1354-8.

AbstractThe aim of this trial was to evaluate the efficacy and safety of intra-articular administration of tranexamic acid (TXA) plus diluted-epinephrine (DEP) on perioperative blood loss and transfusion in primary unilateral total knee arthroplasty (TKA) without drainage. One hundred patients scheduled to undergo TKA were randomized into two groups: 50 patients received intra-articular 3g TXA plus 0.25mg DEP (1:200,000), and 50 patients received 3g topical TXA alone. The results showed that topical combined administration significantly reduced total blood loss (P=0.006), hidden blood loss (P=0.000) and transfusion rate (0% vs. 4%), without increasing the risk of thromboembolic and hemodynamic complications (P>0.05). Therefore, topical TXA plus DEP was effective and safe in reducing blood loss and transfusion following TKA, without substantial complications.Copyright © 2015 Elsevier Inc. All rights reserved.

33 keywords...

hide…