• Christiane Hartog and Frank Bloos.
• Department of Anesthesiology and Intensive Care Medicine, Center for Sepsis Care and Control, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. Electronic address: Christiane.hartog@med.uni-jena.de.
• Best Pract Res Clin Anaesthesiol. 2014 Dec 1;28(4):419-28.

AbstractEarly detection and rapid treatment of tissue hypoxia are important goals. Venous oxygen saturation is an indirect index of global oxygen supply-to-demand ratio. Central venous oxygen saturation (ScvO2) measurement has become a surrogate for mixed venous oxygen saturation (SvO2). ScvO2 is measured by a catheter placed in the superior vena cava. After results from a single-center study suggested that maintaining ScvO2 values >70% might improve survival rates in septic patients, international practice guidelines included this target in a bundle strategy to treat early sepsis. However, a recent multicenter study with >1500 patients found that the use of central hemodynamic and ScvO2 monitoring did not improve long-term survival when compared to the clinical assessment of the adequacy of circulation. It seems that if sepsis is recognized early, a rapid initiation of antibiotics and adequate fluid resuscitation are more important than measuring venous oxygen saturation. Copyright © 2014 Elsevier Ltd. All rights reserved.

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