• Dennis C Gore, David Chinkes, Arthur Sanford, David W Hart, Steven E Wolf, and David N Herndon.
• Department of Surgery-Trauma, The University of Texas Medical Branch, 301 University Blvd, Route 1172, Galveston, TX 77555, USA.
• Arch Surg Chicago. 2003 Feb 1;138(2):169-74; discussion 174.

BackgroundBurn injury typically elicits a hypermetabolic response characterized by increased energy expenditure and muscle protein catabolism.HypothesisFever further increases energy expenditure and muscle loss in otherwise highly hypermetabolic burn patients.DesignRetrospective analysis of experimental study.SettingUniversity hospital.PatientsEighty-four children (aged 2-18 years) with burns covering 40% or more of total body surface area.InterventionsNone.Main Outcome MeasuresSimultaneous measurements of indirect calorimetry and leg net balance of phenylalanine (as an index of muscle protein catabolism) were obtained. Patients were stratified by their rectal temperature taken at the time of these metabolic measurements: afebrile (n = 28; temperature, <39.0 degrees C); mild fever (n = 26; temperature, 39.0 degrees C-39.4 degrees C); moderate fever (n = 18; temperature, 39.5 degrees C-39.9 degrees C); or severe fever (n = 12; temperature, > or =40.0 degrees C).ResultsFebrile and afebrile patients were similar in age, body weight, and extent of burn area. Severe fever was associated with significantly increased resting energy expenditure (mean +/- SD resting energy expenditure-predicted basal, 1.38 +/- 0.39 for afebrile patients vs 1.68 +/- 0.30 for patients with severe fever; P<.05) and a greater net loss of phenylalanine from the leg (net balance of phenylalanine, -6.0 +/- 6.2 mg/min per 100 mL of leg volume for afebrile patients vs -10.8 +/- 7.2 mg/min per 100 mL for patients with severe fever; P<.05). Patient groups were similar in plasma glucose concentration and extent of leukocytosis.ConclusionsThese findings demonstrate the association of severe fever with further increase in energy expenditure and muscle protein catabolism in otherwise hypermetabolic burned children. This suggests a possible metabolic benefit in attenuating fever in such patients.

17 keywords...

hide…