• Am J Emerg Med · Nov 2012

    Case Reports

    Alcoholic ketoacidosis coincides with acute Marchiafava-Bignami disease.

    • Ming-Hua Chen and Chun-An Cheng.
    • Department of Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.
    • Am J Emerg Med. 2012 Nov 1;30(9):2087.e7-8.

    AbstractAlcoholism is the major cause of electrolyte and acid-base imbalance and nutrition deficiency. Ketoacidosis is one of major advised effect on alcoholism. Marchiafava-Bignami disease, a rare alcohol-related disorder, characterized by altered mental status, seizure, and multifocal central nervous system signs, which results from progressive demyelination and necrosis of corpus callosum. Here, we presented a 53-year-old man presented as decreased conscious level and 4 extremity rigidity on admission. Alcoholic ketoacidosis coincided with acute Marchiafava-Bignami disease had been confirmed by biochemistry examination and cranial magnetic resonance imaging. Aggressive hydration with 5% dextrose in normal saline and intravenous vitamin B complex were administered. The patient's symptoms completely recovered after ketoacidosis has been corrected 2 days later.

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