• Jihyero Han, Ji Hyun Lee, Min Jung Kim, and Min Whan Jung.
• Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Korea Advanced Institute of Science and Technology Daejeon, South Korea ; Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine Suwon, South Korea ; Neuroscience Graduate Program, Institute for Medical Sciences, Ajou University School of Medicine Suwon, South Korea.
• Front Neural Circuit. 2013 Jan 1;7:128.

AbstractThe neural circuit consisting of mediodorsal nucleus (MDN) of thalamus and prefrontal cortex (PFC) has been implicated in working memory. In order to investigate whether and how the rodent MDN processes working memory-related signals, we recorded activity of single neurons from the MDN in rats performing a delayed spatial alternation task. The MDN conveyed significant neural signals for the animal's previously chosen goal (retrospective information) in the early delay period, but the signals deteriorated gradually over time so that they became weak toward the end of the delay period. Neural signals for the animal's upcoming goal choice (prospective information) were even weaker than those for the previously chosen goal. These results are in contrast to the finding in monkeys that both MDN and PFC persistently maintain task-related neural signals throughout delay period. Our results do not support sustained MDN-PFC interactions as a general mechanism for mediating working memory across different behavioral tasks and/or animal species.

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