• Gac Med Mex · May 2012

    Review

    [New anticoagulants: dabigatran, rivaroxaban and apixaban].

    • Angel Gabriel Vargas Ruiz, Alba Nydia Ramírez López, and Mónica Elizabeth Medina Viramontes.
    • Departamento de Hematología y Oncología, Instituto Nacional de Nutrición Salvador Zubirán, México, D.F. gelocoa@hotmail.com
    • Gac Med Mex. 2012 May 1;148(3):257-64.

    AbstractTo date, the most widely used drugs in our anticoagulation clinics are acenocoumarin and warfarin, which belong to the category of vitamin K antagonists (VKA). They have about 70 years of use in the clinic, with proven efficacy for various thrombotic diseases, but also with known problems of variability and dietary and drug interactions. In hospital thromboprophylaxis, the most widely used anticoagulant is enoxaparin, a low molecular weight heparin (LMWH). A new generation of anticoagulants are available, the direct thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban and apixaban), with obvious advantages over conventional anticoagulants. This paper summarizes what has been published to date for these new antithrombotics.

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