• Beijing Da Xue Xue Bao · Apr 2011

    Review

    [Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases].

    • Shu Li and Li-ping Duan.
    • Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
    • Beijing Da Xue Xue Bao. 2011 Apr 18;43(2):311-4.

    AbstractTransient receptor potential vanilloid 1(TRPV1) is a nonselective cation channel with high permeability for Ca(2+). It may play a role in the development and maintenance of visceral pain and hypersensitivity states, which has generated a major interest in the development of specific vanilloid antagonists. In this review, a summary of the contribution of TRPV1 in the development of visceral hypersensitivity in functional dyspepsia and irritable bowel syndrome is presented with the structure, location, and related molecular mechanisms.

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