• Asad E Patanwala, Karen L Holmes, and Brian L Erstad.
• Department of Pharmacy Practice & Science, College of Pharmacy, University of Arizona, , Tucson, Arizona, USA.
• Emerg Med J. 2014 Feb 1;31(2):139-42.

ObjectiveThe primary objective of this study was to compare the analgesic response to morphine in non-obese, obese and morbidly obese patients for acute pain.MethodsThis was a retrospective cohort study conducted in a tertiary care emergency department in the USA. Consecutive adults who received intravenous morphine 4 mg for pain were included. Patients were categorised into three groups based on body mass index (BMI): non-obese (18.5-29.9 kg/m(2)); obese (30.0-39.9 kg/m(2)); and morbidly obese (≥40 kg/m(2)). Baseline and post-dose pain scores were recorded. Pain was measured on a 0-10 numerical rating scale (0=no pain; 10=worst possible pain). Analgesic response was defined as the difference between the initial pain score and post-dose pain score.Results300 patients were included in the study (100 in each group). The median baseline pain scores were 8.5, 8 and 8.5 in the non-obese, obese and morbidly obese groups, respectively (p=0.464). The median analgesic response after morphine administration was 2, 3 and 2 in the non-obese, obese and morbidly obese groups, respectively (p=0.160). In the linear regression analysis (R(2)=0.006), BMI was not predictive of analgesic response (coefficient -0.020; p=0.199).ConclusionsObesity status did not influence analgesic response to a fixed dose of morphine. This suggests that obese and morbidly obese patients do not require a higher dose of morphine for acute pain reduction compared to non-obese patients.

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