• Xing Tong, Jiaying Dong, Zhiwei Wu, Wei Li, and Liqiang Qin.
• Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China.
• Wei Sheng Yan Jiu. 2011 Sep 1;40(5):617-9.

ObjectiveTo investigate the effects of whey protein on insulin resistance in model rats.MethodsInsulin resistance model rats were established by feeding high-fat diet in Wistar rats. Model rats were then randomly divided into 4 groups of 10 animals each and fed on 0% whey protein (WP), 5% WP and 15% WP. After 8 weeks, fasting blood glucose (FBG), fasting plasma insulin (FINS) were determined. Oral glucose tolerance test (OGTT) was performed and glucose area under the curve (AUC) was calculated. Also, plasma total anti-oxidation capacity (T-AOC), superoxide dismutase (SOD), reduced glutathione hormone (GSH) and malondialdehyde (MDA) were determined.ResultsWhey protein intake did not affected FBG and glucose AUC. FINS and homeostatic model assessment-insulin resistance (HOMA-IR) were significantly lower in 15% WP group than in 0% WP group. For antioxidant index,plasma level of T-AOC, SOD and GSH were significantly higher in 15% WP group than in 0% WP group (T-AOC : P < 0.01; SOD, GSH : P < 0.05); however, MDA was significantly lower in 15% WP group than in 0% WP group (P < 0.05).ConclusionWhey protein improves insulin resistance. This effect is related to the increase of antioxidant capacity in insulin resistance model rats.

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