• Boris Sepesi, Jacob Moalem, Eva Galka, Peter Salzman, and Luke O Schoeniger.
• Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
• J. Gastrointest. Surg. 2012 Feb 1;16(2):267-74.

BackgroundPancreatic fistula continues to be a source of significant morbidity following distal pancreatic resections. The technique of pancreatic division varies widely among surgeons, and there is no evidence that identifies a single method as superior. In our practice, the technique of distal pancreatic resection has evolved from cut-and-sew to stapled technique with green and recently white cartridge. The aim of our study was to evaluate the rate of clinically significant fistulas [International Study Group on Pancreatic Fistula (ISGPF) grade B or C] following distal pancreatectomy and to identify variables associated with a low rate of fistula development.MethodsClinical records of all patients who underwent distal pancreatic resections between February 1999 and July 2010 by a single surgeon were retrospectively reviewed focusing on the incidence and type of pancreatic fistula as defined by ISGPF. Study variables included age, gender, surgical approach, extent of resection, ASA classification, type of stapler cartridge, use of Seamguard™, and ISGPF classification. Statistical analysis was performed using Fisher's exact test, and univariate and multivariate logistic regression.ResultsSixty-four patients (median age 60, range 21-85; 54% male) underwent distal pancreatic resection (laparoscopy 50% vs. open 50%). The most common indications were pancreatic adenocarcinoma (N = 15; 23%) and neuroendocrine neoplasms (N = 14; 22%). Clinically significant pancreatic fistula developed in 24% (N = 15). The rate of fistula with cut-and-sew technique was 36% (4/11), with stapled green cartridge 31% (9/29) and only 5% (1/21) with stapled vascular cartridge. Univariate logistic regression identified vascular cartridge size (p = 0.04, OR 0.11) and open stapled technique (p = 0.05, OR 0.12) as variables significantly associated with a low fistula rate. Both vascular cartridge size (p = 0.05, OR 0.10) and open stapled technique (p = 0.04, OR 0.08) remained significant when analyzed by multivariate logistic regression. Division of pancreatic parenchyma with vascular cartridges resulted in significantly (p = 0.03, OR 9.0) lower fistula rate compared to green cartridges. The use of Seamguard™ did not affect fistula rate (16% vs. 27%; p = 0.34) nor did the performance of multivisceral resection vs. distal pancreatectomy/splenectomy alone (21% vs. 23%, p = 1.0).ConclusionThe optimal technique of pancreatic division has not been conclusively established. Dividing the pancreas utilizing vascular (2.5 mm) staple cartridges significantly decreased the rate of clinically significant pancreatic fistula and we have changed our practice accordingly. A prospective randomized trial is necessary to validate these results.

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