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Clin. Pharmacol. Ther. · Jan 2009
Clinical TrialThe consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain.
- J Lötsch, K Flühr, T Neddermayer, A Doehring, and G Geisslinger.
- Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Frankfurt am Main, Frankfurt, Germany. j.loetsch@em.uni-frankfurt.de
- Clin. Pharmacol. Ther. 2009 Jan 1;85(1):25-30.
AbstractGenetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism. Given that many of the pain-relevant genetic variants are common (allelic frequencies of 10-50%), we hypothesized that a major reason for difficulties in reproducing demonstrations of genetic influences on pain is the concomitant presence in a single individual of several functional genetic polymorphisms that act as confounders.
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