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Dtsch. Med. Wochenschr. · Mar 1985
Clinical Trial[Long-term therapy of cancer pain. A controlled study on buprenorphine].
- M Zenz, S Piepenbrock, M Tryba, M Glocke, M Everlien, and W Klauke.
- Dtsch. Med. Wochenschr. 1985 Mar 22;110(12):448-53.
AbstractSublingual tablets of buprenorphine (Temgesic sublingual) were given in a controlled trial of 41 patients for 2804 patient-days. With a mean starting dose of 1.09 mg and a final dose of 1.53 mg buprenorphine daily there was a good pain-relieving effect. The interval between doses was six to eight hours. The trial did not reveal any direct pointers as to tolerance or addictiveness after long-term intake of the drug. Because of its effectiveness and good duration of action, as well as the absence of negative long-term effects, the drug can be recommended in the long-term management of cancer pain.
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